Liver fibrosis is driven by protease-activated receptor-1 expressed by hepatic stellate cells in experimental chronic liver injury.

Lauren G PooleAsmita PantHolly M Cline-FedewaKurt J WilliamsBryan L CoppleJoseph S PalumboJames P Luyendyk

Published in: Research and practice in thrombosis and haemostasis (2020)

The results constitute the first direct experimental evidence that PAR-1 expressed by stellate cells directly promotes their profibrogenic phenotype and hepatic fibrosis in vivo.

Keyphrases

liver injury
liver fibrosis
induced apoptosis
drug induced
cell cycle arrest
cell death
endoplasmic reticulum stress
signaling pathway
cell proliferation