Brain Insulin Signaling, Alzheimer Disease Pathology, and Cognitive Function.

Zoe ArvanitakisHoau-Yan WangAna W CapuanoAmber KhanBouchra TaïbFrederick Anokye-DansoJulie A SchneiderDavid A BennettRexford S AhimaSteven E Arnold

Published in: Annals of neurology (2020)

Brain AKT phosphorylation, a critical node in the signaling of insulin and other growth factors, is associated with AD neuropathology and lower cognitive function. ANN NEUROL 2020;88:513-525.

Keyphrases

type diabetes
resting state
white matter
glycemic control
functional connectivity
signaling pathway
cell proliferation
lymph node
metabolic syndrome
protein kinase