Genetic mutational status of genes regulating epigenetics: Role of the histone methyltransferase KMT2D in triple negative breast tumors.

Sara Morcillo-GarciaMaria Del Mar Noblejas-LopezCristina Nieto-JimenezJavier Perez-PeñaMiriam Nuncia-CantareroBalázs GyőrffyEitan AmirAtanasio PandiellaEva Maria Galan-Moya Alberto Ocaña

Published in: PloS one (2019)

In the present work, we describe epigenetic modulating genes which are found to be mutated in breast cancer. We identify the histone methyltransferase KMT2D, which is mutated in 6% of triple negative tumors and linked with poor survival.

Keyphrases

dna methylation
genome wide
gene expression
bioinformatics analysis
copy number
genome wide identification
transcription factor
free survival
young adults