Genetically encoded calcium indicator with NTnC-like design and enhanced fluorescence contrast and kinetics.

D A DoroninN V BarykinaFedor V SubachV P SotskovV V PlusninO A IvlevaE A IsaakovaA M VarizhukG E PozmogovaA Y MalyshevI V SmirnovK D PiatkevichK V AnokhinG N EnikolopovF V Subach

Published in: BMC biotechnology (2018)

We demonstrate that expanding the family of NTnC-like calcium indicators is a promising strategy for the development of the next generation of GECIs with smaller molecule size and lower Ca2+ ions buffering capacity as compared with commonly used GECIs.

Keyphrases

magnetic resonance
single molecule
aqueous solution
quantum dots
contrast enhanced