[Fast HPLC-MS/MS screening method for identification of illegal drugs including new psychoactive substances and their metabolites in human urine].
S A SavchukKsenia M ShestakovaL N RizvanovaD A BurmykinM V OvcharovN V MesonzhnikS A AppolonovaPublished in: Sudebno-meditsinskaia ekspertiza (2020)
Aim of this study was to develop a fast screening method for identification of illegal drugs including new psychoactive substances and their metabolites in human urine by means of liquid chromatography mass-spectrometry HPLC-MS/MS screening method for identification of 138 psychoactive substances in urine was established, validated and tested. High-resolution mass-spectrometry was used for confirmation of the developed approach. The developed method was tested on 50 positive urine samples containing the target compounds, which proved reliability and accuracy of the established screening method.
Keyphrases
- ms ms
- liquid chromatography
- mass spectrometry
- high resolution mass spectrometry
- tandem mass spectrometry
- ultra high performance liquid chromatography
- high performance liquid chromatography
- endothelial cells
- simultaneous determination
- gas chromatography
- drinking water
- solid phase extraction
- high resolution
- bioinformatics analysis