Screening for Circulating Inflammatory Proteins Does Not Reveal Plasma Biomarkers of Constant Tinnitus.

Christopher R CederrothMun-Gwan HongMaxim B FreydinNiklas K EdvallNatalia TrpchevskaCarlotta JarachWinfried SchleeJochen M SchwenkJose-Antonio Lopez-EscamezSilvano GallusBarbara CanlonJan BullaFrances M K Williams

Published in: Journal of the Association for Research in Otolaryngology : JARO (2023)

Our results did not identify significant associations of the selected inflammatory proteins with constant tinnitus. Future studies examining longitudinal relations among those with more severe tinnitus and using more recent expanded proteomics platforms and sampling of cerebrospinal fluid could increase the likelihood of identifying relevant molecular biomarkers.

Keyphrases

cerebrospinal fluid
hearing loss
oxidative stress
mass spectrometry
early onset
gene expression
single cell
single molecule
drug induced
label free