A POETIC Phase II study of continuous oral everolimus in recurrent, radiographically progressive pediatric low-grade glioma.
Karen D WrightXiaopan YaoWendy B LondonPei-Chi KaoLia GoreStephen HungerRuss GeyerKenneth J CohenJeffrey C AllenHoward M KatzensteinAmy SmithJessica BoklanKellie NazemiTanya TrippettMatthias A KarajannisCynthia HerzogJoseph DestefanoJennifer DirenzoJay PietrantonioLianne GreenspanDanielle CassidyDebra SchisselJohn PerentesisMitali BasuTomoyuki MizunoAlexander A VinksSanjay P PrabhuSusan N ChiMark W KieranPublished in: Pediatric blood & cancer (2020)
Daily oral everolimus provides a well-tolerated, alternative treatment for multiple recurrent, radiographically progressive pediatric LGG. Based on these results, everolimus is being investigated further for this patient population.