Chromosome 4q25 variants and biomarkers of myocardial fibrosis in patients with atrial fibrillation.

Jong-Il ChoiYong Soo BaekSeung-Young Roh Jonathan P PicciniYoung-Hoon Kim

Published in: Journal of cardiovascular electrophysiology (2019)

The combination of plasma TIMP-1 concentrations less than 107 ng/mL and the absence of a variant allele at rs10033464 was associated with lower recurrence rates in patients with paroxysmal AF. This study suggests that 4q25 SNPs and biomarkers for fibrosis may provide additive value in risk stratification for AF recurrence after catheter ablation.

Keyphrases

atrial fibrillation
catheter ablation
left atrial
left atrial appendage
copy number
heart failure
left ventricular
genome wide
gene expression
dna methylation
free survival
mitral valve