Disruption of the Golgi protein Otg1 gene causes defective hormone secretion and aberrant glucose homeostasis in mice.

Guangxue WangRongbo LiYing YangLiang CaiSheng DingTian XuMin HanXiaohui Wu

Published in: Cell & bioscience (2016)

Our data support the hypothesis that Otg1 impacts hormone secretion by regulating vesicle trafficking. These results revealed a previously unknown and important role of Otg1 in hormone secretion and glucose homeostasis in mammals.

Keyphrases

blood glucose
genome wide
electronic health record
big data
copy number
high fat diet induced
type diabetes
gene expression
dna methylation
blood pressure
machine learning
deep learning
transcription factor
artificial intelligence
data analysis
glycemic control