Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women.
null nullLeila DorlingSara CarvalhoJamie AllenAnna González-NeiraCraig LuccariniCecilia WahlströmKaren A PooleyMichael T ParsonsCristina FortunoQin WangManjeet K BollaJoe DennisRenske KeemanM Rosario AlonsoNuria ÁlvarezBelen HerraezVictoria FernandezRocio Núñez-TorresAna OsorioJeanette ValcichMinerva LiTherese TörngrenPatricia A HarringtonCaroline BaynesDon M ConroyBrennan DeckerLaura FachalNasim MavaddatThomas AhearnKristiina AittomäkiNatalia N AntonenkovaNorbert ArnoldPatrick ArveuxMargreet G E M AusemsPäivi AuvinenHeiko BecherMatthias W BeckmannSabine BehrensMarina BermishevaKatarzyna BiałkowskaCarl BlomqvistNatalia V BogdanovaNadja Bogdanova-MarkovStig E BojesenBernardo BonanniAnne-Lise Børresen-DaleHiltrud BrauchMichael BremerIgnacio BricenoThomas BrüningBarbara BurwinkelDavid A CameronNicola J CampArchie CampbellAngel CarracedoJose E CastelaoMelissa H CessnaStephen J ChanockHans ChristiansenJ Margriet ColléeEmilie Cordina-DuvergerSten CornelissenKamila CzeneThilo DörkArif B EkiciChristoph EngelMikael ErikssonPeter A FaschingJonine FigueroaHenrik FlygerAsta FörstiMarike GabrielsonManuela Gago-DominguezVassilios GeorgouliasFabian GilGraham G GilesGord GlendonEncarna B Gómez GarciaGrethe I Grenaker AlnæsPascal GuénelAndreas HadjisavvasLothar HaeberleEric HahnenPer HallUte HamannElaine F HarknessJaana M HartikainenMikael HartmanWei HeBernadette A M Heemskerk-GerritsenPeter HillemannsFrans B L HogervorstAntoinette HollestelleWeang Kee HoMaartje J HooningAnthony HowellKeith HumphreysFaiza IdrisAnna JakubowskaAudrey JungPooja Middha KapoorMichael J KerinElza KhusnutdinovaSung-Won KimYon-Dschun KoVeli-Matti KosmaVessela N KristensenKyriacos KyriacouInge M M LakemanJong Won LeeMin Hyuk LeeJingmei LiAnnika LindblomWing-Yee LoMaria A LoizidouArtitaya LophatananonJan LubińskiRobert J MacInnisMichael J MadsenArto MannermaaMehdi ManoochehriSiranoush ManoukianSara MargolinMaría Elena MartínezTabea MaurerDimitrios MavroudisCatriona McLeanAlfons MeindlArjen R MensenkampKyriaki MichailidouNicola MillerNur Aishah Mohd TaibKenneth MuirAnna Marie MulliganHeli NevanlinnaWilliam G NewmanBørge G NordestgaardPei-Sze NgJan C OosterwijkSue K ParkTjoung-Won Park-SimonJose I A PerezPaolo PeterlongoDavid J PorteousKarolina PrajzendancDarya ProkofyevaPaolo RadiceMuhammad U RashidValerie RheniusMatti A RookusThomas RüdigerEmmanouil SaloustrosElinor J SawyerRita K SchmutzlerAndreas SchneeweissPeter SchürmannMitul ShahChristof SohnMelissa C SoutheyHarald M SurowyMaija SuvantoSomchai ThanasitthichaiIan TomlinsonDiana TorresThérèse TruongMaria TzardiYana ValovaChristi J van AsperenRob M Van DamAns M W van den OuwelandLizet E van der KolkElke M van VeenCamilla WendtJustin A WilliamsXiaohong R YangSook-Yee YoonM Pilar ZamoraD Gareth EvansMiguel de la HoyaJacques SimardAntonis C AntoniouÅke BorgIrene L AndrulisJenny Chang-ClaudeMontserrat García-ClosasGeorgia Chenevix-TrenchRoger L MilnePaul D P PharoahMarjanka K SchmidtAmanda B SpurdleMaaike P G VreeswijkJavier BenitezAlison M DunningAnders KvistSoo H TeoPeter DevileeDouglas F EastonPublished in: The New England journal of medicine (2021)
The results of this study define the genes that are most clinically useful for inclusion on panels for the prediction of breast cancer risk, as well as provide estimates of the risks associated with protein-truncating variants, to guide genetic counseling. (Funded by European Union Horizon 2020 programs and others.).