Treatment Response in First-Line Metastatic Pancreatic Ductal Adenocarcinoma Is Stratified By a Composite Index of Tumor Proliferation and CD8 T-Cell Infiltration.
Gregory L BeattyDevora DelmanJiayi YuMingen LiuJoey H LiLiti ZhangJae W LeeRenee B ChangNathan BaharyEugene P KennedyAndrea Wang-GillamGabriela R RossiIgnacio Garrido-LagunaPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Our findings suggest that inhibiting cancer cell proliferation alone in PDA is insufficient to produce tumor responses and support a role for tumor-extrinsic mechanisms, such as CD8+ T cells, which combine with the cancer cell proliferation index to define treatment outcomes.