Alternatives to Low Molecular Weight Heparin for Anticoagulation in Pregnant Women with Mechanical Heart Valves in Middle-Income Countries: A Cohort Study.
Anish KeepanasserilAjith Ananthakrishna PillaiJyoti BaghelSwaraj Nandini PandeNivedita MondalHemachandren MunuswamyPankaj KundraRohan D'SouzaPublished in: Global heart (2021)
Pregnancy complications associated with MHVs in LMICs may be reduced by multidisciplinary surveillance, avoiding first-trimester warfarin if the daily dose is >5 mg, ensuring therapeutic levels of heparin in the first trimester and peripartum period.Placentally-mediated complications of pregnancy can be prevented by administering low-dose aspirin.Vitamin K antagonists or sequential regimen can be used as suitable alternatives to LMWH for anticoagulation in pregnant women with MHVs.
Keyphrases
- venous thromboembolism
- low dose
- pregnant women
- atrial fibrillation
- pregnancy outcomes
- direct oral anticoagulants
- preterm birth
- physical activity
- risk factors
- public health
- heart failure
- growth factor
- mental health
- cardiovascular disease
- quality improvement
- cardiovascular events
- acute coronary syndrome
- transcatheter aortic valve implantation
- percutaneous coronary intervention