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Do Circulating Histones Represent the Missing Link among COVID-19 Infection and Multiorgan Injuries, Microvascular Coagulopathy and Systemic Hyperinflammation?

Daniela LigiRosanna ManiscalcoMaria Rosaria CapobianchiGian Luca SalvagnoFerdinando Mannello
Published in: Journal of clinical medicine (2022)
Several studies shed light on the interplay among inflammation, thrombosis, multi-organ failures and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Increasing levels of both free and/or circulating histones have been associated to coronavirus disease 2019 (COVID-19), enhancing the risk of heart attack and stroke with coagulopathy and systemic hyperinflammation. In this view, by considering both the biological and clinical rationale, circulating histones may be relevant as diagnostic biomarkers for stratifying COVID-19 patients at higher risk for viral sepsis, and as predictive laboratory medicine tool for targeted therapies.
Keyphrases
  • respiratory syndrome coronavirus
  • coronavirus disease
  • sars cov
  • atrial fibrillation
  • oxidative stress
  • clinical trial
  • heart failure
  • intensive care unit
  • acute kidney injury
  • pulmonary embolism
  • cerebral ischemia