Targeted deep sequencing of urothelial bladder cancers and associated urinary DNA: a 23-gene panel with utility for non-invasive diagnosis and risk stratification.

Douglas G WardNaheema S GordonRebecca H BoucherSarah J PirrieLaura BaxterSascha OttLee SilcockCelina M WhalleyJoanne D StocktonAndrew D BeggsMike GriffithsBen AbbottsHanieh IjakipourFathimath N LatheefRobert A RobinsonAndrew J WhiteNicholas D JamesMaurice P ZeegersK K ChengRichard T Bryan

Published in: BJU international (2019)

SMs are reliably detected in urinary cpDNA and cfDNA. The technical capability to identify very low MAFs is essential to reliably detect UBC, regardless of the use of cpDNA or cfDNA. This 23-gene panel shows promise for the non-invasive diagnosis and risk stratification of UBC.

Keyphrases

copy number
genome wide
genome wide identification
spinal cord injury
urinary tract
circulating tumor
single cell
high grade
cell free
single molecule
dna methylation
big data
gene expression
machine learning
drug delivery