Ccl3 enhances docetaxel chemosensitivity in breast cancer by triggering proinflammatory macrophage polarization.

Dandan ShengWei MaRui ZhangLei ZhouQiaodan DengJuchuanli TuWeilong ChenFuchuang ZhangNailong GaoMengxue DongDong WangFengkai LiYin LiuXueyan HeShengzhong DuanLixing ZhangTong LiuSuling Liu

Published in: Journal for immunotherapy of cancer (2022)

Our results indicate that Ccl3 induced by DTX triggers proinflammatory macrophage polarization and subsequently facilitates phagocytosis of cancer cells. Ccl3 induction in combination with DTX may provide a promising therapeutic rationale for increasing DTX chemosensitivity in breast cancer.

Keyphrases

liver fibrosis
liver injury
drug induced
radiation therapy
young adults
breast cancer risk
rectal cancer