Design and protocol of the multimorbidity and mental health cohort study in frailty and aging (MiMiCS-FRAIL): unraveling the clinical and molecular associations between frailty, somatic disease burden and late life depression.

Ivan AprahamianRonei Luciano MamoniNilva Karla CervigneTaize Machado AugustoCarla Vasconcelos RomaniniMarina PetrellaDaniele Lima da CostaNatalia Almeida LimaMarcus K BorgesRichard C Oude Voshaar

Published in: BMC psychiatry (2020)

Frailty might be hypothesized as a final common pathway by which many clinical conditions like depression and chronic diseases (multimorbidity) culminate in many adverse effects. The MiMiCS-FRAIL cohort will help us to understand the interrelationship between these variables, from a clinical perspective as well as their underlying molecular signature.

Keyphrases

mental health
depressive symptoms
gene expression
dna methylation
single molecule
risk factors
copy number