Combined hydroxyurea and ETA receptor blockade reduces renal injury in the humanized sickle cell mouse.

Crystal TaylorMalgorzata KasztanBinli TaoJennifer S PollockDavid M Pollock

Published in: Acta physiologica (Oxford, England) (2018)

These findings indicate that HU and ETA receptor blockade produce similar reductions in renal injury in the humanized sickle mouse suggesting that both treatments may converge on the same mechanistic pathway.

Keyphrases

monoclonal antibody
binding protein
sickle cell disease