Combination of gemcitabine and anti-PD-1 antibody enhances the anticancer effect of M1 macrophages and the Th1 response in a murine model of pancreatic cancer liver metastasis.
Tuyen Thuy Bich HoAlessandro NastiAkihiro SekiTakuya KomuraHiiro InuiTakashi KozakaYoji KitamuraKazuhiro ShibaTaro YamashitaTatsuya YamashitaEishiro MizukoshiKazunori KawaguchiTakashi WadaMasao HondaShuichi KanekoYoshio SakaiPublished in: Journal for immunotherapy of cancer (2021)
The combination of anti-PD-1 antibody immunotherapy with GEM was beneficial to treat a murine model of PDAC liver metastasis by enhancing the immune response mediated by Th1 lymphocytes and M1 macrophages and was associated with CD8+ T cells.