Muscle strength and motor function in adolescents and adults with spinal muscular atrophy.
Camiel A WijngaardeMarloes StamLouise A M OttoBart BartelsFay-Lynn AsselmanRuben P A van EijkLeonard H van den BergH Stephan GoedeeRenske I WadmanLudo W van der PolPublished in: Neurology (2020)
Muscle strength and motor function decline in older patients with SMA are constant without periods of slower progression or a plateau phase. The floor effects of the HFMSE preclude its use for long-term follow-up of adult patients with SMA types 1c through 3a. Muscle strength sum scores represent an alternative, feasible outcome measure for adolescent and adult patients with SMA.