Differences in biomarkers and molecular pathways according to age for patients with HFrEF.
Joao Pedro FerreiraWouter OuwerkerkBernadet T SantemaDirk J van VeldhuisenChim C LangLeong L NgStefan D AnkerKenneth DicksteinMarco MetraJohn G F ClelandSamani J NileshGerasimos S FilippatosJoseph-Pierre AboumsallemRudolf A de BoerSylwia FigarskaIziah E SamaAdriaan A VoorsFaiez ZannadPublished in: Cardiovascular research (2022)
In elderly HFrEF patients, pathways associated with extra-cellular matrix organization, inflammatory processes, and tumour cell regulation were activated, while pathways associated with tumour proliferation functions were down-regulated. These findings may help in a better understanding of the ageing processes in HFrEF and identify potential therapeutic targets.