Phase-based coordination of hippocampal and neocortical oscillations during human sleep.
Roy CoxTheodor RuberBernhard P StaresinaJuergen FellPublished in: Communications biology (2020)
During sleep, new memories undergo a gradual transfer from hippocampal (HPC) to neocortical (NC) sites. Precisely timed neural oscillations are thought to mediate this sleep-dependent memory consolidation, but exactly how sleep oscillations instantiate the HPC-NC dialog remains elusive. Employing overnight invasive electroencephalography in ten neurosurgical patients, we identified three broad classes of phase-based communication between HPC and lateral temporal NC. First, we observed interregional phase synchrony for non-rapid eye movement (NREM) spindles, and N2 and rapid eye movement (REM) theta activity. Second, we found asymmetrical N3 cross-frequency phase-amplitude coupling between HPC slow oscillations (SOs) and NC activity spanning the delta to high-gamma/ripple bands, but not in the opposite direction. Lastly, N2 theta and NREM spindle synchrony were themselves modulated by HPC SOs. These forms of interregional communication emphasize the role of HPC SOs in the HPC-NC dialog, and may offer a physiological basis for the sleep-dependent reorganization of mnemonic content.
Keyphrases
- working memory
- sleep quality
- physical activity
- end stage renal disease
- chronic kidney disease
- ejection fraction
- endothelial cells
- newly diagnosed
- transcranial magnetic stimulation
- depressive symptoms
- resting state
- functional connectivity
- subarachnoid hemorrhage
- patient reported
- prefrontal cortex
- induced pluripotent stem cells