Design and development of selective competitive fluorescent ligands for the detection and visualization of Kv7.2/7.3 in vitro .

Zhen QiaoSiyuan TangJialiang GuanZhengji YinChao ZhuQiqi ZhouLiming Shao

Published in: Chemical communications (Cambridge, England) (2022)

A series of specific and potent fluorescent ligands were developed for labelling and visualizing Kv7.2/7.3 based molecular rotation restriction. Probes 21b and 24a were found to be safe and convenient tools to detect and visualize Kv7.2/7.3 in live cells and mouse brain tissue.

Keyphrases

living cells
label free
image quality
fluorescent probe
single molecule
quantum dots
induced apoptosis
dual energy
cell cycle arrest
small molecule
oxidative stress
endoplasmic reticulum stress
signaling pathway
anti inflammatory
cell proliferation
sensitive detection
photodynamic therapy