Systemic inflammation is linked to liver fibrogenesis in patients with advanced chronic liver disease.

Benedikt Simbrunner Ida Falk VillesenPhilipp KönigshoferBernhard Scheiner David Josef Maria Bauer Rafael Paternostro Philipp SchwablGerald TimelthalerDariga RamazanovaKatharina WöranJudith StiftErnst EigenbauerAlbert Friedrich StättermayerRodrig MarculescuMatthias Pinter Søren MøllerMichael TraunerMorten Asser Karsdal Diana Julie Leeming Thomas Reiberger Mattias Mandorfer

Published in: Liver international : official journal of the International Association for the Study of the Liver (2022)

Systemic inflammation is linked to both liver fibrogenesis and ECM turnover in ACLD and this association is not confounded by the severity of liver disease, as evaluated by HVPG. Our study confirms experimental data on the detrimental impact of SI on ECM deposition and fibrosis progression in a thoroughly characterized cohort of patients with ACLD.

Keyphrases

extracellular matrix
electronic health record
big data
machine learning
deep learning
body composition