ZBP1 Protects Against mtDNA-Induced Myocardial Inflammation in Failing Hearts.

Nobuyuki Enzan Shouji MatsushimaSoichiro IkedaKosuke OkabeAkihito IshikitaTaishi Yamamoto Masashi SadaRyo MiyakeYoshitomo TsutsuiRyohei NishimuraTakayuki ToyoharaYuki IkedaYoko ShojimaHiroko Deguchi Miyamoto Tomonori Tadokoro Masataka Ikeda Kohtaro Abe Tomomi Ide Shintaro KinugawaHiroyuki Tsutsui

Published in: Circulation research (2023)

Our study reveals unexpected protective roles of ZBP1 against cardiac remodeling as an endogenous suppressor of mtDNA-induced myocardial inflammation.

Keyphrases

oxidative stress
left ventricular
diabetic rats
high glucose
copy number
mitochondrial dna
heart failure
endothelial cells