Association of preeclampsia with infant APOL1 genotype in African Americans.

Anna K MillerTimur AzhibekovJohn F O'TooleJohn R SedorScott M WilliamsRaymond W RedlineLeslie A Bruggeman

Published in: BMC medical genetics (2020)

Preeclampsia appears to be another disease associated with APOL1 variants, however, further studies are needed to increase confidence in the mode of inheritance. By understanding the association of APOL1 variants with preeclampsia, genetic screening tests for APOL1 may be useful to predict at-risk pregnancies and targeted interventions may be developed to improve pregnancy outcomes.

Keyphrases

pregnancy outcomes
pregnant women
copy number
early onset
mitochondrial dna
genome wide
gene expression
drug delivery
dna methylation