Tumour-associated macrophages enhance breast cancer malignancy via inducing ZEB1-mediated DNMT1 transcriptional activation.

Zhongwei LiPengfei WangWenjie CuiHongmei YongDiandian WangTiesuo ZhaoWenwen WangMing ShiJun-Nian ZhengJin Bai

Published in: Cell & bioscience (2022)

Our study indicates that DNMT1 is necessary for TAM-mediated breast cancer metastasis. Decitabine (DAC), as a specific DNA methylation inhibitor and FDA-approved drug, is a bona fide drug for breast cancer treatment.

Keyphrases

dna methylation
gene expression
genome wide
epithelial mesenchymal transition
acute myeloid leukemia
long non coding rna
adverse drug
emergency department
young adults
heat shock
breast cancer risk
childhood cancer
heat stress