Combining radiation to EGFR and Bcl-2 blockade: a new approach to target cancer stem cells in head and neck squamous cell carcinoma.

Jean-Baptiste GuySophie EspenelSafa LouatiArnaud GauthierMax-Adrien GarciaNicolas VialCéline MalésysDominique ArdailGersende AlphonseAnne-Sophie WoznyClaire Rodriguez-LafrasseNicolas Magné

Published in: Journal of cancer research and clinical oncology (2021)

Based on the present results, this triple combination therapy may represent a new opportunity for testing in clinical trials, particularly in locally advanced HNSCC.

Keyphrases

combination therapy
cancer stem cells
locally advanced
clinical trial
rectal cancer
small cell lung cancer
neoadjuvant chemotherapy
epidermal growth factor receptor
squamous cell carcinoma
tyrosine kinase
radiation therapy
phase ii study
phase ii
radiation induced
open label
phase iii
double blind
lymph node