The Number of Signaling Pathways Altered by Driver Mutations in Chronic Lymphocytic Leukemia Impacts Disease Outcome.

Christian BrieghelCaspar da Cunha-BangChristina Westmose YdeAne Yde SchmidtSavvas Kinalis Ferran Nadeu Michael Asger AndersenLine Offenbach JacobsenLone Bredo PedersenJulio DelgadoTycho BaumannMattias MattssonLarry MansouriRichard RosenquistElias CampoFinn Cilius NielsenCarsten Utoft Niemann

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

We propose to include the number of pathways altered by driver mutations as a biomarker together with CLL-IPI in prospective studies of CLL from time of diagnosis for incorporation into clinical care and personalized follow-up and treatment.

Keyphrases

chronic lymphocytic leukemia
healthcare
signaling pathway
palliative care
quality improvement
pi k akt
epithelial mesenchymal transition
pain management
combination therapy
cell proliferation