Rictor, an mTORC2 Protein, Regulates Murine Lymphatic Valve Formation Through the AKT-FOXO1 Signaling.
Richa BanerjeeLuz A KnauerDrishya IyerSara E BarlowHanan ShalabyRazieh DehghanJoshua P ScallanYing YangPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
Our work identifies a novel role for RICTOR in the mechanotransduction signaling pathway, wherein it activates AKT and prevents the nuclear accumulation of the valve repressor, FOXO1, which ultimately enables the formation and maintenance of lymphatic valves.
Keyphrases
- signaling pathway
- aortic valve
- pi k akt
- mitral valve
- aortic stenosis
- lymph node
- induced apoptosis
- aortic valve replacement
- transcatheter aortic valve replacement
- epithelial mesenchymal transition
- transcatheter aortic valve implantation
- cell proliferation
- genome wide
- transcription factor
- protein protein
- ejection fraction
- mouse model
- gene expression
- binding protein
- amino acid
- oxidative stress
- dna methylation
- small molecule
- coronary artery disease
- left ventricular