Characterisation of ciclesonide metabolism in human placentae across gestation.
Ashley S MeakinKathryn L GatfordYu-Chin LienMichael D WieseRebecca A SimmonsJanna L Morrison
Published in: Placenta (2024)
Conversion of CIC to des-CIC by the human placenta may preclude its use as a novel GR-agonist in threatened preterm birth. In vivo studies are required to confirm the extent to which placental activation occurs after maternal treatment.