GRAMD4 inhibits tumour metastasis by recruiting the E3 ligase ITCH to target TAK1 for degradation in hepatocellular carcinoma.

Qian Yun GeJin ChenGan Xun LiXiao Long TanJia SongDeng NingJie MoPeng Cheng DuQiu Meng LiuHui Fang LiangZe-Yang DingXue Wu ZhangBi Xiang Zhang

Published in: Clinical and translational medicine (2022)

GRAMD4 inhibits the migration and metastasis of HCC, mainly by recruiting ITCH to promote the degradation of TAK1, which leads to the inactivation of MAPK and NF-κB signalling pathways.

Keyphrases

signaling pathway
pi k akt
oxidative stress
lps induced
cell proliferation
immune response
toll like receptor