Diagnostic accuracy of pulmonary host inflammatory mediators in the exclusion of ventilator-acquired pneumonia.

Thomas P HellyerAndrew Conway MorrisDaniel F McAuleyTimothy S WalshNiall H AndersonSuveer SinghPaul DarkAlistair I RoySimon V BaudouinStephen E WrightGavin D PerkinsKallirroi KefalaMelinda JeffelsRonan McMullanCecilia M O'KaneCraig SpencerShondipon LahaNicole RobinSavita GossainKate GouldMarie-Hélène Ruchaud-SparaganoJonathan ScottEmma M BrowneJames G MacFarlaneSarah WiscombeJohn D WiddringtonIan DimmickIan F LaurensonFrans NauwelaersA John Simpson

Published in: Thorax (2014)

Low BALF IL-1β in combination with IL-8 confidently excludes VAP and could form a rapid biomarker-based rule-out test, with the potential to improve antibiotic stewardship.

Keyphrases

pulmonary hypertension
oxidative stress
acute respiratory distress syndrome
mechanical ventilation
intensive care unit
risk assessment
quantum dots