Diagnosing acute brain dysfunction due to sepsis.
Figen EsenGünseli OrhunPerihan Ergin ÖzcanAndres R Brenes BastosErdem TüzünPublished in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2019)
Developments in the management of critically ill patients suffering organ dysfunctions have demonstrated that brain is the prominent organ to be effected during critical illness. Acute brain dysfunction due to pathologic neuroinflammatory processes associated with sepsis is commonly seen and related to morbidity and mortality in the ICU treatment. Studies reported that survivors of sepsis may suffer long-term cognitive dysfunction that affects quality of life. However, there are no specific approaches to diagnose acute brain dysfunction in the early phase to target protective measures. In recent years, imaging methods and biomarkers are the most important issues of studies. This review will address the current diagnostic approaches to acute brain dysfunction related to sepsis.
Keyphrases
- liver failure
- resting state
- intensive care unit
- white matter
- respiratory failure
- acute kidney injury
- drug induced
- functional connectivity
- septic shock
- aortic dissection
- cerebral ischemia
- squamous cell carcinoma
- young adults
- multiple sclerosis
- mass spectrometry
- mechanical ventilation
- brain injury
- acute respiratory distress syndrome
- combination therapy