Login / Signup

Allogeneic Stem Cell Transplantation in Mantle Cell Lymphoma; Insights into Its Potential Role in the Era of New Immunotherapeutic and Targeted Therapies: The GETH/GELTAMO Experience.

Antonio GutierrezLeyre BentoSilvana NovelliAlejandro Martin Martin Garcia-SanchoGonzalo GutierrezMaría Queralt SalasMariana Bastos-OreiroAriadna PerezRafael HernaniMaría Cruz ViguriaOriana Lopez-GodinoJuan MontoroJosé Luis PiñanaChristelle FerraRocio ParodyCarmen MartinIgnacio EspañolLucrecia YañezGuillermo RodriguezJoud ZanabiliPilar HerreraMaria Rosario VarelaAntonia SampolCarlos SolanoDolores Caballeronull On Behalf Of The Grupo Español de Trasplante de Progenitores Hematopoyéticos Geth And Grupo Español de Linfoma Y Trasplante Autólogo Geltamo
Published in: Cancers (2022)
Allo-SCT is a curative option for selected patients with relapsed/refractory (R/R) MCL, but with significant NRM. We present the long-term results of patients receiving allo-SCT in Spain from March 1995 to February 2020. The primary endpoints were EFS, OS, and cumulative incidence (CI) of NRM, relapse, and GVHD. We included 135 patients, most (85%) receiving RIC. After a median follow-up of 68 months, 5-year EFS and OS were 47 and 50%, respectively. Overall and CR rates were 86 and 80%. The CI of relapse at 1 and 3 years were 7 and 12%. NRM at day 100 and 1 year were 17 and 32%. Previous ASCT and Grade 3-4 aGVHD were associated with a higher NRM. Grade 3-4 aGVHD, donor type (mismatch non-related), and the time-period 2006-2020 were independently related to worse EFS. Patients from 1995-2005 were younger, most from HLA-identical sibling donors, and were pretreated less. Our data confirmed that allo-SCT may be a curative option in R/R MCL with low a CI of relapse, although NRM is still high, being mainly secondary to aGVHD. The arrival of new, highly effective and low toxic immunotherapeutic or targeted therapies inevitably will relegate allo-SCT to those fit patients who fail these therapies, far away from the optimal timing of treatment.
Keyphrases