A novel facile one-pot synthesis of photothermally responsive carbon polymer dots as promising drug nanocarriers.
Grazia Maria Letizia ConsoliMaria Laura GiuffridaCristina SatrianoTeresa MusumeciGiuseppe ForteSalvatore PetraliaPublished in: Chemical communications (Cambridge, England) (2022)
Luminescent and photothermic carbon polymer dots (CPDs-PNM), composed of a carbonized core and cross-linked chains of poly( N -isopropylacrylamide), were synthetized by a novel, simple, solvent- and reagent-free method. The formation of CPDs-PNM was controlled by both temperature and heating time. The CPDs-PNM exhibited LCST behaviour, high photothermal conversion efficiency, curcumin loading capacity and no toxicity to eukaryotic cells. Proof of concept experiments confirmed an excellent thermally induced drug release activity to be used for photothermally controlled drug release.
Keyphrases
- drug release
- drug delivery
- induced apoptosis
- light emitting
- quantum dots
- cancer therapy
- fluorescent probe
- cell cycle arrest
- oxidative stress
- high glucose
- molecularly imprinted
- drug induced
- diabetic rats
- metal organic framework
- sensitive detection
- ionic liquid
- emergency department
- cell death
- adverse drug
- endothelial cells
- mass spectrometry
- reduced graphene oxide
- photodynamic therapy
- solar cells
- electronic health record