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Regulation of MRTF-A by JMY via a nucleation-independent mechanism.

Franziska KlugeJulia WeissbachAnja WeberTheresia StradalGuido Posern
Published in: Cell communication and signaling : CCS (2018)
Our results suggest that JMY activates MRTF-SRF independently of F-actin via WH2/V-mediated competition with the RPEL region for G-actin binding in the cytoplasm. Furthermore, the C-terminal region facilitates an autoinhibitory effect on full-length JMY, possibly by intramolecular folding.
Keyphrases
  • molecular dynamics simulations
  • dna binding
  • energy transfer