Adipose tissue and blood leukocytes ACE2 DNA methylation in obesity and after weight loss.
Andrea G IzquierdoMarcos C CarreiraHatim BoughanemJose M Moreno-NavarreteCarolina F NicolettiPaula OliverDaniel de LuisCarla B NoninoMaria P PortilloMiguel A Martinez-OlmosJose M Fernandez-RealFrancisco J TinahonesJ Alfredo MartinezManuel Macias-GonzálezFelipe F CasanuevaAna Belén CrujeirasPublished in: European journal of clinical investigation (2021)
Obesity-related VAT shows hypermethylation and downregulation of the ACE2 gene that is mirrored in PBMCs and is restored after nutritional weight reduction therapy. The results warrant the necessity to further evaluate its implication for COVID-19 pathogenesis.
Keyphrases
- weight loss
- bariatric surgery
- adipose tissue
- dna methylation
- roux en y gastric bypass
- insulin resistance
- weight gain
- genome wide
- gastric bypass
- angiotensin converting enzyme
- coronavirus disease
- angiotensin ii
- sars cov
- metabolic syndrome
- gene expression
- high fat diet
- copy number
- type diabetes
- glycemic control
- body mass index
- signaling pathway
- peripheral blood
- physical activity
- skeletal muscle
- body weight