The combination of oral-recombinant methioninase and azacitidine arrests a chemotherapy-resistant osteosarcoma patient-derived orthotopic xenograft mouse model.

Takashi HiguchiNorihiko SugisawaJun YamamotoHiromichi OshiroQinghong HanNorio YamamotoKatsuhiro HayashiHiroaki KimuraShinji MiwaKentaro IgarashiYuying TanShreya KuchipudiMichael BouvetShree Ram SinghHiroyuki TsuchiyaRobert M Hoffman

Published in: Cancer chemotherapy and pharmacology (2019)

This study suggests that o-rMETase-AZA combination has clinical potential for patients with chemoresistant osteosarcoma.

Keyphrases

mouse model
acute myeloid leukemia
squamous cell carcinoma
risk assessment
human health
cell free
cardiac arrest