Allergic airway inflammation delays glioblastoma progression and reinvigorates systemic and local immunity in mice.
Aurélie PoliAnaïs OudinArnaud MullerIlaria SalvatoAndrea ScafidiOliver HunewaldOlivia DominguesPetr V NazarovVincent PuardVirginie BausFrancisco AzuajeGunnar DittmarJacques ZimmerTatiana MichelAlessandro MichelucciSimone P NiclouMarkus OllertPublished in: Allergy (2022)
Our results demonstrate that AAI limits both tumor take and progression in mice, providing a preclinical model to study the impact of allergy on GBM susceptibility and prognosis, respectively. We identify a potentiation of local and adaptive systemic immunity, suggesting a reciprocal crosstalk that orchestrates allergy-induced immune protection against GBM.