Application of diffusion-weighted whole-body MRI for response monitoring in multiple myeloma after chemotherapy: a systematic review and meta-analysis.

Kaiwen WangElsa LeeShedrack KenisSimon HallamAthar HaroonSimon WanNeil RabinAntonio Rojas-GarciaAnwar PadhaniSola Adeleke

Published in: European radiology (2022)

• In multiple myeloma patients who received chemotherapy, responders have a significant absolute increase in ADC values that is not seen in non-responders. • A 35% increase in ADC from baseline values is found to classify response post-induction chemotherapy which corroborates with expert opinion from the Myeloma Response Assessment and Diagnosis System. • More evidence is needed to further characterise ADC changes by lesion subtypes over time after induction of therapy.

Keyphrases

diffusion weighted
contrast enhanced
multiple myeloma
diffusion weighted imaging
magnetic resonance imaging
magnetic resonance
stem cells
radiation therapy
mesenchymal stem cells
clinical practice