STING protects against cardiac dysfunction and remodelling by blocking autophagy.

Rui XiongNing LiLei ChenWei WangBo WangWenyang JiangQing Geng

Published in: Cell communication and signaling : CCS (2021)

STING may prevent cardiac remodelling induced by pressure overload by inhibiting autophagy, which could be a promising therapeutic target in heart failure. Video Abstract.

Keyphrases

heart failure
signaling pathway
left ventricular
oxidative stress
cell death
endoplasmic reticulum stress
atrial fibrillation
cardiac resynchronization therapy