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BRCA1 and BRCA2 germline mutations in Chinese Hakka breast cancer patients.

Yinmei ZhangHeming WuCaiyan GanHui RaoQiuming WangXueming Guo
Published in: BMC medical genomics (2024)
The most common pathogenic variant of the BRCA1 and BRCA2 in breast cancer patients was c.2635G > T and c.5164_5165del, respectively. Additionally, a family history of cancer, bilateral cancer, HER2-, and Ki67 ≥ 15% were identified as independent predictors of BRCA1/2 pathogenic variants.
Keyphrases
  • breast cancer risk
  • papillary thyroid
  • squamous cell
  • gene expression
  • copy number
  • dna repair
  • neoadjuvant chemotherapy
  • lymph node