Interleukin-17A Is Produced by CD4+ but Not CD8+ T Cells in Synovial Fluid Following T Cell Receptor Activation and Regulates Different Inflammatory Mediators Compared to Tumor Necrosis Factor in a Model of Psoriatic Arthritis Synovitis.

Xiaofei XuNadine DavelaarAnne-Marie MusPatrick S AsmawidjajaJohanna M W HazesDominique L P BaetenMarijn VisRadjesh J BisoendialErrol P PrensErik Lubberts

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)

CD8+ T cells, in contrast to CD4+ T cells, in SF specimens obtained from PsA patients did not secrete IL-17A following T cell receptor activation. Overlapping, but distinct, effects at the level of inflammatory cytokines and MMPs were found after neutralizing IL-17A or TNF ex vivo in a human model of PsA synovitis.

Keyphrases

prostate cancer
rheumatoid arthritis
end stage renal disease
endothelial cells
ejection fraction
newly diagnosed
magnetic resonance
radical prostatectomy
peritoneal dialysis
oxidative stress
patient reported outcomes
contrast enhanced
ultrasound guided