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X marks the spot in autoimmunity.

Alessio GerussiChiara CaimeEleonora BinattiClaudio CappadonaLaura CristoferiRosanna AsseltaM Eric GershwinInvernizzi Pietro
Published in: Expert review of clinical immunology (2022)
There is growing evidence that many genes present on chrX escape inactivation, and some of them have significant immune-mediated functions. In immune cells of female individuals the escape of these genes is not constant, but the knowledge of the mechanisms controlling this plasticity are not completely understood. Future studies aimed at the characterization of these modifications at single-cell resolution, together with conformational 3D studies of the inactive X chromosome, will hopefully help to fill this gap of knowledge.
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