A new benzoquinone, guxiumasperone A ( 1 ), and a new diisoprenyl-cyclohexene-type meroterpenoids, biscognienyne M ( 2 ), along with four known diisoprenyl-cyclohexene analogues was isolated from the mangrove endophytic fungus Aspergillus QG1a. Their structures were determined by extensive spectral analysis of 1D and 2D NMR, HR-ESI- MS, and X-ray crystallography. Compound 1 was deduced by a single-crystal X-ray diffraction analysis, and the absolute configuration of 2 was further unequivocally elucidated by comparing the experimental electronic circular dichroism (ECD) data with calculated ECD spectra. Compounds 1 and 2 showed significant cytotoxic activity against selected tumour cells. Particularly, compound 2 exhibited strong activity against A2780 cancer cells with an IC 50 value of 6.8 μ M.
Keyphrases
- high resolution
- ms ms
- dual energy
- induced apoptosis
- mass spectrometry
- electron microscopy
- multiple sclerosis
- cell cycle arrest
- computed tomography
- magnetic resonance
- molecular docking
- electronic health record
- big data
- solid state
- cell death
- cell wall
- magnetic resonance imaging
- signaling pathway
- machine learning
- data analysis
- artificial intelligence