Multiplexed immunohistochemical analysis of the immune microenvironment of biliary tract cancers pre- & post-neoadjuvant chemotherapy: case series.

Sirish DharmapuriRafael CabalGuray AkturkGiorgio IoannouSinem OzbeyJohn PaulsenSheen RainaCelina AngUmut SarpelMax W SungPeter KozuchMyron E SchwartzDeirdre Jill CohenSacha GnjaticSofya Pintova

Published in: Annals of translational medicine (2024)

Preliminary results suggest NACT may differentially modulate various compartments of the immune tumor contexture despite overall cell depletion. Future studies should focus on strategies to expand immune modulation of tumor microenvironment, including immune-oncology agents to augment the effects of chemotherapy.

Keyphrases

neoadjuvant chemotherapy
locally advanced
single cell
stem cells
lymph node
palliative care
squamous cell carcinoma
early stage
cell therapy
mesenchymal stem cells
case control