Tenapanor administration and the activity of the H+ -coupled transporter PepT1 in healthy volunteers.

Susanne JohanssonDavid P RosenbaumJohan PalmBergur StefanssonMikael KnutssonEleanor A LisbonConstanze Hilgendorf

Published in: British journal of clinical pharmacology (2017)

These results suggest that tenapanor 15 mg twice daily does not have a clinically relevant impact on the activity of the H+ -coupled transporter PepT1 in humans. This may guide future research on drug-drug interactions involving NHE3 inhibitors.

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