Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression.
Emmanuelle BornLarissa LipskaiaMarielle BreauAmal HoussainiDelphine Paulette BeaulieuElisabeth MarcosRémi PierreMarcio Do CruzeiroMarine LefevreGenevieve DerumeauxDmitry V BulavinMarion DelcroixRozenn QuarckVirinder ReenJesús GilDavid BernardJean-Michel FlamanSerge AdnotShariq AbidPublished in: Circulation (2022)
Elimination of senescent P-ECs by senolytic interventions may worsen pulmonary hemodynamics. These results invite consideration of the potential impact on pulmonary vessels of strategies aimed at controlling cell senescence in various contexts.