Plasminogen-induced foam cell formation by macrophages occurs through a histone 2B (H2B)-PAR1 pathway and requires integrity of clathrin-coated pits.

Lahoucine IzemKatarzyna BialkowskaElzbieta PluskotaMitali DasRiku DasMarvin T NiemanEdward F Plow

Published in: Journal of thrombosis and haemostasis : JTH (2021)

Our data indicate that the magnitude of Plg-FCF by macrophages is proportional to the H2B levels and demonstrate for the first time that PAR1 is involved in this process and that the integrity of clathrin-coated pits is required for the full effect of Plg-induced FCF.

Keyphrases

high glucose
diabetic rats
single cell
dna methylation
stem cells
endothelial cells
electronic health record
big data
artificial intelligence