Severe Candida glabrata pancolitis and fatal Aspergillus fumigatus pulmonary infection in the setting of bone marrow aplasia after CD19-directed CAR T-cell therapy - a case report.
Marion SubkleweWolfgang G KunzMartina RudeliusVeit BückleinViktoria BlumenbergChristian SchmidtPhilipp KarschniaFlorian SchöberlKonstantin DimitriadisLouisa von BaumgartenJoachim StemmlerOliver WeigertMartin DreylingMichael von Bergwelt-BaildonMarion SubklewePublished in: BMC infectious diseases (2021)
This case highlights the increased risk for fatal infectious complications in patients who present with profound and prolonged cytopenia after CAR T-cell therapy. We describe a rare case of C. glabrata pancolitis associated with multifactorial immunosuppression. Although our patient succumbed to a fatal fungal infection, autologous stem cell boost was able to spur hematopoiesis and may represent an important therapeutic strategy for DLBCL patients with CAR T-cell associated bone marrow aplasia who have underwent prior stem cell harvest.